- Date*HomeAwayVenueScore
- Sat., Mar. 19 6:00 p.m.Colorado RapidsPortland TimbersDSG Park1-3 L
- Sat., Mar. 26 10:30 a.m.Toronto FCPortland TimbersBMO Field0-2
- Tues., Mar. 29 6:30 p.m.Portland TimbersChivas USAUniv. of Portland – Merlo Field (U.S. Open Cup Play-in Game)2-0
- Sat., Apr. 2 4pNew England RevolutionPortland TimbersGillette Stadium 1-1
- Thurs., Apr. 14 730pPortland TimbersChicago FireJeld-Wen Field 4-2
- Sun., Apr. 17 230pPortland TimbersFC DallasJeld-Wen Field 3-2
- Sat., Apr. 23 730pLA GalaxyPortland TimbersThe Home Depot Center
- Sat., Apr. 30 7pPortland TimbersReal Salt LakeJeld-Wen Field
- Fri., May 6 7pPortland TimbersPhiladelphia UnionJeld-Wen Field
- Sat., May 14 730pSeattle Sounders FCPortland TimbersQwest Field
- Sat., May 21 730pPortland TimbersColumbus CrewJeld-Wen Field
- Wed., May 25 630pPortland TimbersAFC AjaxJeld-Wen Field
- Sun., May 29 130pPortland TimbersD.C. UnitedJeld-Wen Field
- Sat., Jun. 4 7pChivas USAPortland TimbersThe Home Depot Center
- Sat., Jun. 11 7pPortland TimbersColorado RapidsJeld-Wen Field
- Sun., Jun. 19 630pPortland TimbersNew York Red BullsJeld-Wen Field
- Sat., Jun. 25 5pFC DallasPortland TimbersPizza Hut Park
- Sat., Jul. 2 730pPortland TimbersSporting Kansas CityJeld-Wen Field
- Sun., Jul 10 130pPortland TimbersSeattle Sounders FCJeld-Wen Field
- Sat., Jul 16 5pChicago FirePortland TimbersToyota Park
- Sat., Jul 23 430pColumbus CrewPortland TimbersColumbus Crew Stadium
- Sat., Jul 30 730pPortland TimbersToronto FCJeld-Wen Field
- Wed., Aug 3 730pPortland TimbersLA GalaxyJeld-Wen Field
- Sat., Aug. 6 7pSan Jose EarthquakesPortland TimbersBuck Shaw Stadium
- Sun., Aug. 14 530pHouston DynamoPortland TimbersRobertson Stadium
- Wed., Aug. 17 5pSporting Kansas CityPortland TimbersLIVESTRONG Sporting Park
- Sat., Aug. 20 630pPortland TimbersVancouver Whitecaps FCJeld-Wen Field
- Wed., Aug. 24 730pPortland TimbersChivas USAJeld-Wen Field
- Sat., Aug. 27 4pD.C. UnitedPortland TimbersRFK Stadium
- Sat., Sept. 10 4pPhiladelphia UnionPortland TimbersPPL Park
- Fri., Sept. 16 730pPortland TimbersNew England RevolutionJeld-Wen Field
- Wed., Sept. 21 7pPortland TimbersSan Jose EarthquakesJeld-Wen Field
- Sat., Sept. 24 4pNew York Red BullsPortland TimbersRed Bull Arena
- Sun., Oct. 2 1pVancouver Whitecaps FCPortland TimbersBC Place
- Fri., Oct. 14 7pPortland TimbersHouston DynamoJeld-Wen Field
- Sat., Oct. 22 530pReal Salt LakePortland TimbersRio Tinto Stadium
* Tiempo del Pacifico/Pre-Juego
